PIGS Gene Summary [Human]
This gene encodes a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PIGS |
| Official Name | phosphatidylinositol glycan anchor biosynthesis class S [Source:HGNC Symbol;Acc:HGNC:14937] |
| Ensembl ID | ENSG00000087111 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol glycan anchor biosynthesis class S, GPI transamidase subunit |
| Synonyms | DEE95, Gm393, Gm689, GPIBD18, phosphatidylinositol glycan anchor biosynthesis class S, phosphatidylinositol glycan anchor biosynthesis, class S |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIGS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphatidylinositol-glycan biosynthesis class S protein
- enzyme
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIGS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- attachment of GPI anchor to protein
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- GPI-anchor transamidase complex
Molecular Function
What the gene product does at the molecular level
- protein binding