SLC15A1 Gene Summary [Human]
This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]
Details
| Type | Protein Coding |
| Official Symbol | SLC15A1 |
| Official Name | solute carrier family 15 member 1 [Source:HGNC Symbol;Acc:HGNC:10920] |
| Ensembl ID | ENSG00000088386 |
| Bio databases IDs | |
| Aliases | solute carrier family 15 member 1, peptide transporter HPEPT1, bA551M18.1.1 (solute carrier family 15 (oligopeptide transporter) member 1), solute carrier family 15 oligopeptide transporter member 1 |
| Synonyms | D630032F02, HPECT1, HPEPT1, H+ peptide transporter, PECT1, PEPT1, pH-Sensing Regulatory Factor of Peptide Transporter, solute carrier family 15 member 1, solute carrier family 15 (oligopeptide transporter), member 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC15A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amide transporter
- transmembrane domain
- Major Facilitator Superfamily
- channel inhibitor
- peptide:hydrogen symporter
- proton-dependent oligopeptide transporter
- tripeptide transporter
- peptide:H+ symporter family
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cleft palate
- colorectal cancer
- inflammatory bowel disease
- experimentally-induced arthritis
- diabetes mellitus
- infection by bacteria
regulates
- Ca2+
- cephalexin
- growth hormone
- peptide
- Gly-Sar
- oligopeptide
- cefadroxil
- pro-inflammatory cytokine
- N(2)-(gamma-D-glutamyl)-meso-2,2'-diaminopimelic acid
- sitagliptin
role in cell
- transport in
- depolarization in
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- basolateral membrane
- sinusoidal membrane
- brush border
- brush border membrane vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC15A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- protein transport
- peptide transport
Cellular Component
Where in the cell the gene product is active
- brush border
- membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- dipeptide transmembrane transporter activity
- peptide:hydrogen symporter activity
- proton-dependent oligopeptide secondary active transmembrane transporter activity
- tripeptide transporter activity