XPR1 Gene Summary [Human]
The protein encoded by this gene is a receptor for the xenotropic and polytropic classes of murine leukemia viruses. The encoded protein is involved in phosphate homeostasis by mediating phosphate export from the cell. Defects in this gene have been associated with idiopathic basal ganglia calcification-6. [provided by RefSeq, Jun 2016]
Details
| Type | Protein Coding |
| Official Symbol | XPR1 |
| Official Name | xenotropic and polytropic retrovirus receptor 1 [Source:HGNC Symbol;Acc:HGNC:12827] |
| Ensembl ID | ENSG00000143324 |
| Bio databases IDs | |
| Aliases | xenotropic and polytropic retrovirus receptor 1, solute carrier family 53 (phosphate exporter), member 1 |
| Synonyms | IBGC6, LOC108353304, Rmc-1, SLC53A1, Sxv, SYG1, X3, xenotropic and polytropic retrovirus receptor 1, XR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human XPR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Syg1, Pho81, XPR1, and related proteins
- inorganic phosphate transporter
- binding protein
- efflux permease
- viral receptor
- EXS family
- SPX domain
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic basal ganglia calcification type 6
- FeCl3 induced thrombosis
- pulmonary embolism
- infection by Xenotropic MuLV-related virus
- infection by mink cell focus-forming virus
role in cell
- proliferation
- cell death
- apoptosis
- cell viability
- phosphorylation in
- expression in
- production in
- sphere formation
- invasion by
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human XPR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- phosphate ion transport
- cellular response to phosphate starvation
- response to virus
- phosphate ion transmembrane transport
- cellular phosphate ion homeostasis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- inorganic phosphate transmembrane transporter activity
- efflux transmembrane transporter activity
- inositol hexakisphosphate binding
- viral receptor activity