SLC35B2 Gene Summary [Human]
Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]
Details
| Type | Processed Transcript |
| Official Symbol | SLC35B2 |
| Official Name | solute carrier family 35 member B2 [Source:HGNC Symbol;Acc:HGNC:16872] |
| Ensembl ID | ENSG00000157593 |
| Bio databases IDs | |
| Aliases | solute carrier family 35 member B2 |
| Synonyms | 1110003M08Rik, Dsm-1, HLD26, PAPST1, Slc35b1, SLL, solute carrier family 35 member B2, solute carrier family 35, member B2, UGTrel4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC35B2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UAA transporter family
- protein binding
- 3'-phosphoadenosine 5'-phosphosulfate transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypomyelinating leukodystrophy type 26 with chondrodysplasia
role in cell
- binding
- activation in
- endocytosis by
- vemurafenib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC35B2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chondroitin sulfate biosynthetic process
- transmembrane transport
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- 3'-phosphoadenosine 5'-phosphosulfate transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- antiporter activity
- 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity