GMIP Gene Summary [Human]
This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Details
| Type | Protein Coding |
| Official Symbol | GMIP |
| Official Name | GEM interacting protein [Source:HGNC Symbol;Acc:HGNC:24852] |
| Ensembl ID | ENSG00000089639 |
| Bio databases IDs | |
| Aliases | GEM interacting protein |
| Synonyms | 5031419I10Rik, ARHGAP46, GEM INTERACTING, GEM interacting protein, RGD1565577 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GMIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- flagellar export protein FliJ
- protein kinase C conserved region 1 (C1 domain) superfamily
- GTPase activator
- enzyme
- protein binding
- Bin/Amphiphysin/Rvs domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- major depression
regulates
- actin
- GTPase
- RHOA
role in cell
- activation in
- exocytosis by
- polymerization
- vesicle transport in
- signal transduction in
- polymerization in
- vesicle transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GMIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of GTPase activity
- regulation of small GTPase mediated signal transduction
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- GTPase activator activity