Gmip Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in intracellular signal transduction; negative regulation of GTPase activity; and negative regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in brain; gonad; and thyroid gland. Orthologous to human GMIP (GEM interacting protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gmip |
| Official Name | Gem-interacting protein [Source:MGI Symbol;Acc:MGI:1926066] |
| Ensembl ID | ENSMUSG00000036246 |
| Bio databases IDs | |
| Aliases | Gem-interacting protein |
| Synonyms | 5031419I10Rik, ARHGAP46, GEM INTERACTING, GEM interacting protein, RGD1565577 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gmip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- flagellar export protein FliJ
- protein kinase C conserved region 1 (C1 domain) superfamily
- GTPase activator
- enzyme
- protein binding
- Bin/Amphiphysin/Rvs domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gmip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of GTPase activity
- regulation of small GTPase mediated signal transduction
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- GTPase activator activity