CPSF3 Gene Summary [Human]
This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012]
Details
| Type | Protein Coding |
| Official Symbol | CPSF3 |
| Official Name | cleavage and polyadenylation specific factor 3 [Source:HGNC Symbol;Acc:HGNC:2326] |
| Ensembl ID | ENSG00000119203 |
| Bio databases IDs | |
| Aliases | cleavage and polyadenylation specific factor 3 |
| Synonyms | cleavage and polyadenylation specific factor 3, cleavage and polyadenylation specificity factor 3, CPSF-73, Cpsf 73kDa, NEDMHS, NEDMHSN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CPSF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta-lactamase superfamily domain
- Beta-Casp domain
- Metallo-beta-lactamase superfamily
- metal ion binding
- 5'-3' exoribonuclease
- endoribonuclease
- enzyme
- protein binding
- Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
- metallo-hydrolase-like_MBL-fold
- RNA binding
- Zn-dependent metallo-hydrolase RNA specificity domain
Pathways
Biological processes and signaling networks where the CPSF3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- organismal death
- neurodevelopmental disorder with microcephaly, hypotonia, nystagmus, and seizures
- liver cancer
- epithelial cancer
- neurodevelopmental disorder with hypotonia, microcephaly, and seizures
- bladder cancer
role in cell
- migration
- expression in
- proliferation
- differentiation
- biogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CPSF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of G1/S transition of mitotic cell cycle
- histone mRNA 3'-end processing
- mRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- mRNA cleavage and polyadenylation specificity factor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 5'-3' exoribonuclease activity
- protein binding
- RNA binding
- metal ion binding
- endoribonuclease activity