BLVRB Gene Summary [Human]
Enables biliverdin reductase (NAD(P)+) activity and riboflavin reductase (NADPH) activity. Involved in heme catabolic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | BLVRB |
| Official Name | biliverdin reductase B [Source:HGNC Symbol;Acc:HGNC:1063] |
| Ensembl ID | ENSG00000090013 |
| Bio databases IDs | |
| Aliases | biliverdin reductase B, short chain dehydrogenase/reductase family 43U, member 1 |
| Synonyms | biliverdin reductase B, Bilverdin reductase, BVRB, FLR, HEL-S-10, Image:3967600, SDR43U1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BLVRB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- biliverdin reductase
- Rossmann-fold NAD(P)(+)-binding proteins
- nitrogenous group transferase
- TrkA-N domain
- flavin reductase
- enzyme
- protein binding
- NAD(P)H-binding
Pathways
Biological processes and signaling networks where the BLVRB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- aortic valve calcification
- sickle cell anemia
- renal cell carcinoma
- renal cell cancer
role in cell
- phosphorylation in
- differentiation
- nitrosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BLVRB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- megakaryocyte differentiation
- heme catabolic process
- negative regulation of insulin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- FMN reductase (NADH) activity
- riboflavin reductase (NADPH) activity
- protein binding
- FMN reductase (NADPH) activity
- biliverdin reductase activity
- FMN reductase activity
- peptidyl-cysteine S-nitrosylase activity