Blvrb Gene Summary [Mouse]
Enables peptidyl-cysteine S-nitrosylase activity. Involved in negative regulation of insulin receptor signaling pathway. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and terminal bouton. Predicted to be active in cytoplasm. Is expressed in liver; nervous system; respiratory system; and sensory organ. Orthologous to human BLVRB (biliverdin reductase B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Blvrb |
| Official Name | biliverdin reductase B (flavin reductase (NADPH)) [Source:MGI Symbol;Acc:MGI:2385271] |
| Ensembl ID | ENSMUSG00000040466 |
| Bio databases IDs | |
| Aliases | biliverdin reductase B (flavin reductase (NADPH)) |
| Synonyms | biliverdin reductase B, Bilverdin reductase, BVRB, FLR, HEL-S-10, Image:3967600, SDR43U1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Blvrb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- biliverdin reductase
- Rossmann-fold NAD(P)(+)-binding proteins
- nitrogenous group transferase
- TrkA-N domain
- flavin reductase
- enzyme
- protein binding
- NAD(P)H-binding
Pathways
Biological processes and signaling networks where the Blvrb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- aortic valve calcification
- sickle cell anemia
- renal cell carcinoma
- renal cell cancer
role in cell
- phosphorylation in
- differentiation
- nitrosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Blvrb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- megakaryocyte differentiation
- heme catabolic process
- negative regulation of insulin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- FMN reductase (NADH) activity
- riboflavin reductase (NADPH) activity
- protein binding
- FMN reductase (NADPH) activity
- biliverdin reductase activity
- FMN reductase activity
- peptidyl-cysteine S-nitrosylase activity