NUDC Gene Summary [Human]
This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | NUDC |
| Official Name | nuclear distribution C, dynein complex regulator [Source:HGNC Symbol;Acc:HGNC:8045] |
| Ensembl ID | ENSG00000090273 |
| Bio databases IDs | |
| Aliases | nuclear distribution C, dynein complex regulator |
| Synonyms | c15, HNUDC, LOC100911422, MNUDC, NPD011, nuclear distribution C, dynein complex regulator, nudC nuclear distribution protein, SIG-92, Silg92 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NUDC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CS domain
- N-terminal conserved domain of Nudc
- alpha-crystallin Hsps/p23-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- expression in
- formation
- formation in
- migration
- maturation
- transport in
- misalignment in
- organization
- misalignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- spindle apparatus
- Nucleus
- midbody
- cytosol
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NUDC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic spindle organization
- nuclear migration
- protein folding
- mitotic metaphase plate congression
- response to peptide hormone stimulus
Cellular Component
Where in the cell the gene product is active
- mitotic spindle
- cytoplasm
- spindle
- cytosol
- midbody
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- unfolded protein binding