MARK2 Gene Summary [Human]
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Details
| Type | Protein Coding |
| Official Symbol | MARK2 |
| Official Name | microtubule affinity regulating kinase 2 [Source:HGNC Symbol;Acc:HGNC:3332] |
| Ensembl ID | ENSG00000072518 |
| Bio databases IDs | |
| Aliases | microtubule affinity regulating kinase 2, ELKL motif kinase 1, serine/threonine kinase, protein-serine/threonine kinase, Ser/Thr protein kinase PAR-1B |
| Synonyms | AU024026, Emk, EMK-1, LOC60328, MAP/microtubule affinity regulating kinase 2, microtubule affinity regulating kinase 2, PAR-1, Par-1b |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MARK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- aPKC binding domain
- central domain
- protein binding
- magnesium ion binding
- Protein kinase domain
- activation loop
- phosphorylation site
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Tau-protein kinase
- Protein Kinases, catalytic domain
- tau protein binding
- AMPKA_C_like
- spacer domain
- Kinase associated domain 1
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MARK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- hypoglycemia
- weight gain
- splenomegaly
- pervasive developmental disorder
- proteinuria
- lymphadenopathy
- major depression
- glomerulonephritis
- growth failure
role in cell
- expression in
- accumulation
- phosphorylation in
- proliferation
- binding
- formation
- migration
- integrity
- growth
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cellular membrane
- focal adhesions
- Nucleus
- Plasma Membrane
- Mitochondria
- actin filaments
- microtubule bundles
- lateral plasma membrane
- nucleoplasm
- neurites
- actin stress fibers
- perikaryon
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MARK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of microtubule cytoskeleton organization
- protein autophosphorylation
- microtubule cytoskeleton organization
- protein phosphorylation
- mitochondrion degradation
- neuron migration
- regulation of axonogenesis
- regulation of cytoskeleton organization
- establishment or maintenance of epithelial cell apical/basal polarity
- establishment or maintenance of cell polarity regulating cell shape
- Wnt receptor signaling pathway
- activation of protein kinase activity
- establishment of cell polarity
- positive regulation of neuron projection development
- peptidyl-serine phosphorylation
- mitochondrion localization
- peptidyl-threonine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- dendrite
- lateral plasma membrane
- cytoplasm
- mitochondrion
- membrane
- actin filament
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- magnesium ion binding
- ATP binding
- protein binding
- RNA binding
- protein kinase activator activity
- cadherin binding
- tau protein binding
- lipid binding
- protein serine/threonine kinase activity