ERBIN Gene Summary [Human]
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | ERBIN |
| Official Name | erbb2 interacting protein [Source:HGNC Symbol;Acc:HGNC:15842] |
| Ensembl ID | ENSG00000112851 |
| Bio databases IDs | |
| Aliases | erbb2 interacting protein, densin-180-like protein, ERBB2-interacting protein |
| Synonyms | 1700028E05Rik, Erbb2i, Erbb2 interacting protein, ERBB2IP, HEL-S-78, LAP2, LOC100361629, mKIAA1225, RGD1562952 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ERBIN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- smad binding domain
- Leucine rich repeat
- canonical PDZ domain
- Neu/ErbB-2 receptor binding
- protein binding
- receptor binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
Pathways
Biological processes and signaling networks where the ERBIN gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- tumorigenesis
- idiopathic scoliosis
- endometriosis
- hypomyelination
- mechanical hypersensitivity
- decreased nerve conduction velocity
- squamous-cell carcinoma
- squamous cell cancer
- cardiac hypertrophy
role in cell
- generation in
- phosphorylation in
- proliferation
- quantity
- differentiation
- senescence
- abnormal morphology
- response by
- autophagy by
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic plasma membrane fractions
- postsynaptic density (PSD) fractions
- membrane fraction
- pH resistant lipid raft fraction
- glutaminergic synapse
- cell junction
- organelle
- postsynaptic region
- Nucleus
- Plasma Membrane
- hemidesmosomes
- cell-cell contacts
- basolateral membrane
- lateral plasma membrane
- nuclear speckles
- neuromuscular junctions
- paranodes
- synaptosomes
- sarcolemma
- dendrites
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ERBIN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of NF-kappaB transcription factor activity
- response to muramyl dipeptide
- signal transduction
- epidermal growth factor receptor signaling pathway
- intermediate filament cytoskeleton organization
- cell adhesion
- protein targeting
- integrin-mediated signaling pathway
- establishment or maintenance of epithelial cell apical/basal polarity
- basal protein localization
- cellular response to tumor necrosis factor
- response to lipopolysaccharide
- negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- negative regulation of monocyte chemotactic protein-1 production
Cellular Component
Where in the cell the gene product is active
- nucleus
- basal plasma membrane
- basement membrane
- nuclear membrane
- cytoplasm
- nuclear speck
- cell junction
- neuromuscular junction
- hemidesmosome
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ErbB-2 class receptor binding
- structural constituent of cytoskeleton
- receptor binding