BTAF1 Gene Summary [Human]
This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | BTAF1 |
| Official Name | B-TFIID TATA-box binding protein associated factor 1 [Source:HGNC Symbol;Acc:HGNC:17307] |
| Ensembl ID | ENSG00000095564 |
| Bio databases IDs | |
| Aliases | B-TFIID TATA-box binding protein associated factor 1, Mot1 homolog (S. cerevisiae) |
| Synonyms | AI414500, B-TFIID TATA-box binding protein associated factor 1, E430027O22Rik, KIAA0940, MOT1, RGD1564130, TAF170, TAF172, TAFII170, TAF(II)170 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BTAF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- SNF2-related domain
- helicase superfamily c-terminal domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- transcription cofactor
- DEAD-like helicases superfamily
- Domain of unknown function (DUF3535)
- DNA dependent ATPase
- Helicase conserved C-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BTAF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of chromatin binding
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- ATP binding
- DNA-dependent ATPase activity
- transcription cofactor activity
- helicase activity
- TBP-class protein binding