UHRF2 Gene Summary [Human]
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | UHRF2 |
| Official Name | ubiquitin like with PHD and ring finger domains 2 [Source:HGNC Symbol;Acc:HGNC:12557] |
| Ensembl ID | ENSG00000147854 |
| Bio databases IDs | |
| Aliases | ubiquitin like with PHD and ring finger domains 2, Np95-like ring finger protein |
| Synonyms | 2310065A22Rik, D130071B19Rik, DKFZp434B0920, NIRF, RNF107, TDRD23, ubiquitin-like, containing PHD and RING finger domains 2, ubiquitin like with PHD and ring finger domains 2, URF2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UHRF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- PHD zinc finger
- SUMO transferase activity
- ubiquitin protein ligase activity
- protein binding activity, bridging
- transcription factor binding
- enzyme
- Tandem tudor domain within UHRF1
- Ring finger domain
- protein binding
- Ubiquitin family
- Ubl1_cv_Nsp3_N-like
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- SAD/SRA domain
- Ubiquitin homologues
- PHD finger superfamily
- Tudor domain superfamily
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- colorectal cancer
- periodontitis
- neoplasia
- organismal death
- metastasis
- nonalcoholic fatty liver disease
role in cell
- accumulation in
- expression in
- proliferation
- apoptosis
- cell death
- degradation in
- accumulation
- binding in
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- nucleoplasm
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UHRF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- cell differentiation
- hypermethylation of CpG island
- regulation of cell cycle
- protein autoubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- centromeric heterochromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding
- histone binding
- SUMO ligase activity