NUBP2 Gene Summary [Human]
This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Details
| Type | Retained Intron |
| Official Symbol | NUBP2 |
| Official Name | nucleotide binding protein 2 [Source:HGNC Symbol;Acc:HGNC:8042] |
| Ensembl ID | ENSG00000095906 |
| Bio databases IDs | |
| Aliases | nucleotide binding protein 2, NUBP iron-sulfur cluster assembly factor 2, cytosolic |
| Synonyms | CFD1, CIAO6, D17Wsu11e, NBP 2, NUBP1, NUBP iron-sulfur cluster assembly factor 2, NUBP iron-sulfur cluster assembly factor 2, cytosolic, NUBP iron-sulphur cluster assembly factor 2, NUBP iron-sulphur cluster assembly factor 2, cytosolic, nucleotide binding protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NUBP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CobQ/CobB/MinD/ParA nucleotide binding domain
- nucleotide binding
- septum site-determining protein MinD
- NUBPL iron-transfer P-loop NTPase
- protein binding
- capsular exopolysaccharide family
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the NUBP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NUBP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell projection organization
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- spindle pole centrosome
- nucleus
- centriole
- cilium
- cytosol
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- ATP binding
- protein binding
- metal ion binding
- 4 iron, 4 sulfur cluster binding
- iron-sulfur cluster binding