QPCT Gene Summary [Human]
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | QPCT |
| Official Name | glutaminyl-peptide cyclotransferase [Source:HGNC Symbol;Acc:HGNC:9753] |
| Ensembl ID | ENSG00000115828 |
| Bio databases IDs | |
| Aliases | glutaminyl-peptide cyclotransferase, glutaminyl cyclase |
| Synonyms | 5730422A13Rik, GCT, glutaminyl cyclase, glutaminyl-peptide cyclotransferase, glutaminyl-peptide cyclotransferase (glutaminyl cyclase), QC, Qpctl1, RGD1562284, sQC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human QPCT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glutaminyl-peptide cyclotransferase
- Zinc peptidases M18, M20, M28, and M42
- zinc ion binding
- enzyme
- protein binding
- Peptidase family M28
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- septic shock
- chronic lymphocytic leukemia
- systemic lupus erythematosus
- aldosterone producing adrenocortical adenoma
- Alzheimer disease
- thyroid carcinoma
- epithelial thyroid cancer
- gliosis
- metastatic colorectal cancer
role in cell
- expression in
- growth
- formation
- migration
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- organelle lumens
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human QPCT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- specific granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- glutaminyl-peptide cyclotransferase activity
- zinc ion binding
- protein binding