TBKBP1 Gene Summary [Human]
TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | TBKBP1 |
| Official Name | TBK1 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:30140] |
| Ensembl ID | ENSG00000198933 |
| Bio databases IDs | |
| Aliases | TBK1 binding protein 1 |
| Synonyms | 3110043L15Rik, KIAA0775, ProSAPiP2, SINTBAD, TBK1 binding protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TBKBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TBK1/IKKi-binding domain
- TBD domain
- Zn-C2H2_CALCOCO1_TAX1BP1_like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TBKBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to virus
- type I interferon-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding