CIT Gene Summary [Human]
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | CIT |
| Official Name | citron rho-interacting serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:1985] |
| Ensembl ID | ENSG00000122966 |
| Bio databases IDs | |
| Aliases | citron rho-interacting serine/threonine kinase, serine/threonine kinase 21 |
| Synonyms | C030025P15RIK, Cit-k, citron, CITRON K, citron rho-interacting serine/threonine kinase, CRIK, CRIK-SK, MCPH17, STK21 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CIT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Autophagy protein 16 (ATG16)
- Ciliary protein causing Leber congenital amaurosis disease
- Synaptonemal complex protein 1 (SCP-1)
- Type III cell invasion protein SipB
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- helix-rich Mycoplasma protein
- transcription factor binding
- enzyme
- Protein kinase domain
- chromosome segregation protein SMC, common bacterial type
- Tropomyosin
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- PH domain
- iSH2_PI3K_IA_R
- Tyrosine kinase, catalytic domain
- HOOK protein coiled-coil region
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Protein kinase (unclassified specificity)
- protein kinase binding
- Hyaluronan mediated motility receptor N-terminal
- Protein tyrosine and serine/threonine kinase
- rad50
- CNH domain
- Myosin tail
- protein binding
- Pleckstrin homology-like domain
- Calcium binding and coiled-coil domain (CALCOCO1) like
- PDZ-domain binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Alpha helical coiled-coil rod protein (HCR)
- RecF/RecN/SMC N terminal domain
- PSD 95 binding domain
- RIM-binding protein of the cytomatrix active zone
- protein serine/threonine kinase inhibitor
- Protein Kinases, catalytic domain
- Trichohyalin-plectin-homology domain
- Coiled-coil domain-containing protein 158
- Intermediate filament protein
- Rho-binding domain
- Septation ring formation regulator, EzrA
Pathways
Biological processes and signaling networks where the CIT gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- COVID-19
- autosomal recessive primary microcephaly type 17
- ulcerative colitis
- hereditary disorder
- ataxia
- idiopathic scoliosis
- inflammatory bowel disease
- sporadic schizophrenia
- seizures
role in cell
- quantity
- signaling in
- replication in
- apoptosis
- formation
- colony formation
- cell viability
- cytokinesis
- differentiation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- ruffle
- organelle
- actin cytoskeleton
- Nucleus
- vacuole
- midbody
- cytoplasmic particles
- cytosol
- dendritic spines
- synapse
- Golgi cisternae
- cleavage furrow
- perikaryon
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CIT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of hippo signaling cascade
- cytokinesis after mitosis
- generation of neurons
- neuron apoptotic process
- mitotic cell cycle
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- ATP binding
- protein kinase binding
- protein serine/threonine kinase inhibitor activity
- protein binding
- metal ion binding
- PDZ domain binding
- SH3 domain binding
- protein serine/threonine kinase activity
- transcription coactivator binding