LGALS2 Gene Summary [Human]
The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LGALS2 |
| Official Name | galectin 2 [Source:HGNC Symbol;Acc:HGNC:6562] |
| Ensembl ID | ENSG00000100079 |
| Bio databases IDs | |
| Aliases | galectin 2 |
| Synonyms | 2200008F12Rik, GAL2, galectin 2, HL14, lectin, galactose-binding, soluble 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LGALS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- GLECT
- galactoside binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- dextran sodium sulfate-induced colitis
- susceptibility to myocardial infarction
- organismal death
- myocardial infarction
- colorectal cancer
- delayed hypersensitive reaction
- colorectal neoplasia
- gastrointestinal neoplasia
- metastatic colorectal cancer
role in cell
- proliferation
- phosphorylation in
- apoptosis
- number
- homeostasis
- cell-cell adhesion
- polarization in
- transmembrane potential
- exposure in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LGALS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of inflammatory response
- positive regulation of apoptotic process
- T cell homeostasis
Molecular Function
What the gene product does at the molecular level
- protein binding
- galactoside binding
- carbohydrate binding