Lgals2 Gene Summary [Mouse]
Predicted to enable carbohydrate binding activity and galactoside binding activity. Involved in positive regulation of inflammatory response. Predicted to be part of galectin complex. Is expressed in yolk sac endoderm. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human LGALS2 (galectin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lgals2 |
| Official Name | lectin, galactose-binding, soluble 2 [Source:MGI Symbol;Acc:MGI:895068] |
| Ensembl ID | ENSMUSG00000043501 |
| Bio databases IDs | |
| Aliases | lectin, galactose-binding, soluble 2 |
| Synonyms | 2200008F12Rik, GAL2, galectin 2, HL14, lectin, galactose-binding, soluble 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lgals2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- GLECT
- galactoside binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- dextran sodium sulfate-induced colitis
- susceptibility to myocardial infarction
- organismal death
- myocardial infarction
- colorectal cancer
- delayed hypersensitive reaction
- colorectal neoplasia
- gastrointestinal neoplasia
- metastatic colorectal cancer
role in cell
- proliferation
- phosphorylation in
- apoptosis
- number
- homeostasis
- cell-cell adhesion
- polarization in
- transmembrane potential
- exposure in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lgals2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of inflammatory response
- positive regulation of apoptotic process
- T cell homeostasis
Molecular Function
What the gene product does at the molecular level
- protein binding
- galactoside binding
- carbohydrate binding