TRIM16 Gene Summary [Human]
The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017]
Details
| Type | Protein Coding |
| Official Symbol | TRIM16 |
| Official Name | tripartite motif containing 16 [Source:HGNC Symbol;Acc:HGNC:17241] |
| Ensembl ID | ENSG00000221926 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 16, estrogen-responsive B box protein |
| Synonyms | 9130006M08Rik, EBBP, ESTROGEN-RESPONSIVE B BOX, tripartite motif-containing 16 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- B-box-type zinc finger superfamily
- SPRY domain
- B-box zinc finger
- coiled-coil domain
- protein domain specific binding
- protein binding
- interleukin-1 binding
- associated with SPRY domains
- SPRY-associated domain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic obstructive pulmonary disease
- ductal breast carcinoma
- ductal breast cancer
- uterine serous papillary cancer
- endometrium tumor
role in cell
- differentiation
- permeabilization
- permeabilization in
- senescence
- dysfunction in
- dysfunction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- cytosol
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte differentiation
- positive regulation of retinoic acid receptor signaling pathway
- response to retinoic acid
- positive regulation of transcription, DNA-dependent
- response to organophosphorus
- response to growth hormone stimulus
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- PML body
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- NACHT domain binding
- transferase activity
- interleukin-1 binding