IKBKG Gene Summary [Human]
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | IKBKG |
| Official Name | inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [Source:HGNC Symbol;Acc:HGNC:5961] |
| Ensembl ID | ENSG00000269335 |
| Bio databases IDs | |
| Aliases | inhibitor of nuclear factor kappa B kinase regulatory subunit gamma, NF-kappa-B essential modulator, IkB kinase-associated protein 1, I-kappa-B kinase subunit gamma, IkB kinase subunit gamma, 14.7K (adenovirus E3 protein) interacting protein 3 |
| Synonyms | 1110037D23Rik, AMCBX1, EDAID1, FIP-3, Fip3p, I Kappa B Gamma, IKBK3, IkB γ, IKK3, IKKAP1, IKKG, IKK[g], IKK-gamma, IKK-γ, IMD33, inhibitor of kappaB kinase gamma, inhibitor of kappaB kinase γ, inhibitor of nuclear factor kappa B kinase regulatory subunit gamma, inhibitor of nuclear factor κ B kinase regulatory subunit γ, IP, IP1, IP2, IPD2, I κ B γ, NEMO, NEMO RELATED, SAIDX, ZC2HC9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IKBKG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C2H2 type zinc-finger
- NEMO ubiquitin-binding domain
- protein binding activity, bridging
- coiled-coil domain
- leucine zipper domain
- identical protein binding
- NF-kappa-B essential modulator NEMO
- proline rich domain
- leucine-rich repeat
- peroxisome proliferator activated receptor binding
- ubiquitin binding domain
- Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
- IKK binding domain
- ubiquitin protein ligase binding
- leucine rich domain
- IKK alpha/beta binding domain
- UBAN motif
- alpha helix
- ubiquitin binding
- protein domain specific binding
- protein binding
- receptor binding
- phosphorylation site
- kinase
- NEMO-binding domain
- binding protein
- Tank binding domain
- protein homodimerization
- zinc finger domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the IKBKG gene in human plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- Antioxidant Action of Vitamin C
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- IL-17A Signaling in Airway Cells
- IL-6 Signaling
- Induction of Apoptosis by HIV1
- LPS-stimulated MAPK Signaling
- Lymphotoxin β Receptor Signaling
- Myc Mediated Apoptosis Signaling
- NF-κB Activation by Viruses
- NF-κB Signaling
- PEDF Signaling
- Primary Immunodeficiency Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- experimental autoimmune encephalomyelitis
- anhidrotic ectodermal dysplasia with immune deficiency
- hereditary disorder
role in cell
- production in
- expression in
- apoptosis
- phosphorylation in
- cell death
- quantity
- activation in
- formation
- formation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- insoluble fractions
- cytoplasmic fiber
- Cytoplasm
- perinuclear region
- Mitochondria
- immunological synapses
- cytoplasmic particles
- granules
- cytosol
- nucleoplasm
- spindle pole
- membrane rafts
- mitotic spindle
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IKBKG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- macromolecular complex assembly
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- anoikis
- positive regulation of transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- I-kappaB kinase/NF-kappaB cascade
- response to virus
- positive regulation of NF-kappaB transcription factor activity
- defense response to bacterium
- positive regulation of T cell receptor signaling pathway
- inflammatory response
- immune response
- establishment of vesicle localization
- innate immune response
- apoptotic process
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- mitotic spindle
- cytoplasm
- IkappaB kinase complex
- spindle pole
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein domain specific binding
- protein binding
- protein homodimerization activity
- ubiquitin protein ligase binding
- K63-linked polyubiquitin binding
- polyubiquitin binding
- signaling adaptor activity
- metal ion binding
- protein heterodimerization activity