ANXA4 Gene Summary [Human]
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
Details
| Type | Processed Transcript |
| Official Symbol | ANXA4 |
| Official Name | annexin A4 [Source:HGNC Symbol;Acc:HGNC:542] |
| Ensembl ID | ENSG00000196975 |
| Bio databases IDs | |
| Aliases | annexin A4 |
| Synonyms | AIV, annexin A4, ANNEXIN IV, ANX4, HEL-S-274, P32.5, PAP-II, PIG28, PP4-X, Xanx-4, ZAP36 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANXA4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- NF-kappaB binding
- calcium ion binding
- calcium-dependent phospholipid binding
- Annexin
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- myocardial infarction
- colon carcinoma
- colon epithelial cancer
- colorectal cancer
- cold thyroid nodule
- Waldenström macroglobulinemia
- tinnitus
- autoimmune pancreatitis
role in cell
- apoptosis
- activation in
- production in
- phosphorylation in
- transactivation in
- sealing
- interaction in
- curvature
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- membrane surface
- cellular membrane
- Nucleus
- Golgi Apparatus
- lipid droplets
- cytosol
- vesicle membrane
- apical membrane
- nuclear envelope
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANXA4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- Notch signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- signal transduction
- negative regulation of interleukin-8 production
- negative regulation of apoptotic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- vesicle membrane
- plasma membrane
- zymogen granule membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- phosphatidylserine binding
- identical protein binding
- protein binding
- calcium ion binding
- phospholipase inhibitor activity
- calcium-dependent protein binding
- calcium-dependent phospholipid binding