SNU13 Gene Summary [Human]

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
SNU13
Official Name
small nuclear ribonucleoprotein 13 [Source:HGNC Symbol;Acc:HGNC:7819]
Ensembl ID
ENSG00000100138
Bio databases IDs NCBI: 4809 Ensembl: ENSG00000100138
Aliases small nuclear ribonucleoprotein 13, small nuclear ribonucleoprotein 15.5kDa (U4/U6.U5)
Synonyms 15.5K, FA-1, Fta1, NHP2L1, NHPX, OTK27, small nuclear ribonucleoprotein 13, SNRNP15-5, SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5), SPAG12, SSFA1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SNU13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ATPase binding
  • U4 snRNA binding
  • Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
  • U4/U6.U5 small nuclear ribonucleoprotein SNU13
  • snoRNA binding
  • protein binding
  • U4atac snRNA binding

Pathways

Biological processes and signaling networks where the SNU13 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • infection by vesicular stomatitis virus
regulated by
  • seocalcitol
  • poly rI:rC-RNA
  • FLI1
  • hexamethylene bisacetamide
  • geldanamycin
  • Major late
  • lnc-SERINC1-8
  • MYCL
role in cell
  • splicing by
  • processing in
  • binding
  • homologous recombination in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • pre-ribosome
  • Plasma Membrane
  • spliceosomes
  • dense fibrillar component
  • nucleoplasm
  • nucleoli

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SNU13 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • box C/D snoRNP assembly
  • maturation of SSU-rRNA
  • ribosomal small subunit biogenesis
  • single fertilization
  • nuclear mRNA splicing, via spliceosome

Cellular Component

Where in the cell the gene product is active
  • box C/D snoRNP complex
  • small-subunit processome
  • nucleus
  • precatalytic spliceosome
  • U4atac snRNP
  • U4/U6 x U5 tri-snRNP complex
  • macromolecular complex
  • U2-type precatalytic spliceosome
  • nucleolus
  • nucleoplasm
  • dense fibrillar component

Molecular Function

What the gene product does at the molecular level
  • RNA binding
  • protein binding
  • snoRNA binding
  • box C/D snoRNA binding
  • U3 snoRNA binding
  • U4atac snRNA binding
  • U4 snRNA binding
  • ATPase binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.