HDLBP Gene Summary [Human]
The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | HDLBP |
| Official Name | high density lipoprotein binding protein [Source:HGNC Symbol;Acc:HGNC:4857] |
| Ensembl ID | ENSG00000115677 |
| Bio databases IDs | |
| Aliases | high density lipoprotein binding protein |
| Synonyms | 1110005P14Rik, D1Ertd101e, HBP, high density lipoprotein binding protein, high density lipoprotein (HDL) binding protein, HLDBP, PRO2900, VGL, vigilin, Vigilin high-density lipoprotein bp |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HDLBP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- K homology (KH) RNA-binding domain, type I
- KH domain
- protein binding
- K homology RNA-binding domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic obstructive pulmonary disease
- metastasis
- coronary artery disease
- prostatic carcinoma
- prostate cancer
- epithelial cancer
- progressive familial intrahepatic cholestasis type 1
- ischemic stroke
- chronic lymphocytic leukemia
role in cell
- expression in
- epithelial-mesenchymal transition
- invasion by
- binding in
- degradation in
- crizotinib sensitivity
- recruitment in
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- Endoplasmic Reticulum
- polysomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HDLBP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- cholesterol metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- high-density lipoprotein particle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- cadherin binding
- mRNA binding
- lipid binding