TTLL12 Gene Summary [Human]
Enables H4K20me3 modified histone binding activity and tubulin binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and regulation of mitotic cell cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TTLL12 |
| Official Name | tubulin tyrosine ligase like 12 [Source:HGNC Symbol;Acc:HGNC:28974] |
| Ensembl ID | ENSG00000100304 |
| Bio databases IDs | |
| Aliases | tubulin tyrosine ligase like 12 |
| Synonyms | D430005B17, dJ526I14.2, KIAA0153, RGD1305319, tubulin tyrosine ligase like 12, tubulin tyrosine ligase-like family, member 12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TTLL12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- tubulin binding
- protein binding activity, bridging
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TTLL12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- innate immune response
- negative regulation of type I interferon-mediated signaling pathway
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- spindle
- cytosol
- midbody
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- ATP binding
- protein binding
- tubulin-tyrosine ligase activity