GGH Gene Summary [Human]
This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | GGH |
| Official Name | gamma-glutamyl hydrolase [Source:HGNC Symbol;Acc:HGNC:4248] |
| Ensembl ID | ENSG00000137563 |
| Bio databases IDs | |
| Aliases | gamma-glutamyl hydrolase, conjugase, folylpolygammaglutamyl hydrolase |
| Synonyms | gamma-GH, gamma-glutamyl hydrolase, GATD10, GH, LOC102549738, LOC667301, γ-GH, γ-glutamyl hydrolase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GGH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase C26
- gamma-glutamyl hydrolase
- Glutamine amidotransferase class-I
- cysteine-type peptidase
- omega peptidase
- peptidase
- protein binding
- Type 1 glutamine amidotransferase (GATase1)-like domain
- exopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- side effect
- diabetes mellitus
- small cell lung cancer
- Dukes stage C colorectal cancer
- colon cancer
- bone marrow toxicity
- septic shock
regulates
- methotrexate
- folic acid
- methotrexate polyglutamate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- azurophil granule lumen
- Extracellular Space
- organelle lumens
- lysosome
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GGH gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tetrahydrofolylpolyglutamate metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- specific granule lumen
- melanosome
- extracellular region
- vacuole
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- protein binding
- omega peptidase activity
- exopeptidase activity
- gamma-glutamyl-peptidase activity