TYRO3 Gene Summary [Human]
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | TYRO3 |
| Official Name | TYRO3 protein tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:12446] |
| Ensembl ID | ENSG00000092445 |
| Bio databases IDs | |
| Aliases | TYRO3 protein tyrosine kinase |
| Synonyms | Brt, BYK, Dtk, Etk-2, etk2/tyro3, Rek, RSE, Sky, Tif, tk19-1, TK19-2, Tyro2, TYRO3 protein tyrosine kinase, TYRO3 protein tyrosine kinase 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TYRO3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- viral receptor
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- cytoplasmic domain
- Immunoglobulin like
- intracellular domain
- immunoglobulin-like protein domain
- Tyrosine kinase, catalytic domain
- Immunoglobulin V-set domain
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- Purple acid Phosphatase, N-terminal domain
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- phosphoinositide 3-kinase binding
- Protein Kinases, catalytic domain
- FN3
- transmembrane domain
- tyrosine kinase domain
Pathways
Biological processes and signaling networks where the TYRO3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- advanced non-small cell lung cancer
- breast cancer
- neoplasia
- metastatic non-small cell lung cancer
- autoimmune disease
- progressive non-small cell lung cancer
- differentiated thyroid cancer
- tall cell variant of papillary thyroid carcinoma
- advanced hepatocellular carcinoma
- well-differentiated neuroendocrine tumor
role in cell
- activation in
- proliferation
- expression in
- differentiation
- phosphorylation in
- apoptosis
- cell death
- cellular infiltration by
- survival
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- cell surface
- cellular membrane
- Nucleus
- endoplasmic reticulum membrane
- nuclear envelope
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TYRO3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- vagina development
- multicellular organismal development
- nervous system development
- protein autophosphorylation
- negative regulation of lymphocyte activation
- cell adhesion
- negative regulation of innate immune response
- ovulation cycle
- negative regulation of neuron apoptotic process
- protein kinase B signaling cascade
- neuron migration
- substrate adhesion-dependent cell spreading
- positive regulation of kinase activity
- establishment of localization in cell
- platelet aggregation
- cell migration
- platelet activation
- secretion by cell
- neuron apoptotic process
- negative regulation of toll-like receptor signaling pathway
- signal transduction
- negative regulation of inflammatory response
- spermatogenesis
- apoptotic cell clearance
- forebrain cell migration
- transmembrane receptor protein tyrosine kinase signaling pathway
- neuropeptide signaling pathway
- neuron homeostasis
- natural killer cell differentiation
- phagocytosis
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- nucleus
- receptor complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ATP binding
- phosphatidylinositol 3-kinase binding
- protein tyrosine kinase activity
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- viral receptor activity