SOCS6 Gene Summary [Human]
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SOCS6 |
| Official Name | suppressor of cytokine signaling 6 [Source:HGNC Symbol;Acc:HGNC:16833] |
| Ensembl ID | ENSG00000170677 |
| Bio databases IDs | |
| Aliases | suppressor of cytokine signaling 6 |
| Synonyms | 1500012M23RIK, 5830401B18Rik, AI447482, CIS-4, Cish4, HSPC060, SOCS-4, SSI4, STAI4, STAT4, STATI4, suppressor of cytokine signaling 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SOCS6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- elongin B/C binding domain
- SOCS
- Src homology 2 (SH2) domain
- protein binding
Pathways
Biological processes and signaling networks where the SOCS6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- pervasive developmental disorder
- COVID-19
- global developmental delay with intellectual disability
role in cell
- proliferation
- expression in
- ubiquitination in
- degradation in
- growth
- activation
- remodeling in
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- immunological synapses
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SOCS6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- phosphatidylinositol phosphorylation
- negative regulation of T cell activation
- defense response
- regulation of growth
- intracellular signal transduction
- protein ubiquitination
- proteasomal protein catabolic process
- JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex
- cytoplasm
- cytosol
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- 1-phosphatidylinositol-3-kinase regulator activity