PAPLN Gene Summary [Human]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to be located in basement membrane. Predicted to be active in extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PAPLN |
| Official Name | papilin, proteoglycan like sulfated glycoprotein [Source:HGNC Symbol;Acc:HGNC:19262] |
| Ensembl ID | ENSG00000100767 |
| Bio databases IDs | |
| Aliases | papilin, proteoglycan like sulfated glycoprotein |
| Synonyms | E030033C16Rik, PAPILIN, papilin, proteoglycan-like sulfated glycoprotein, papilin, proteoglycan-like sulphated glycoprotein, PPN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PAPLN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Immunoglobulin C1-set domain
- Linking region between Kunitz_BPTI and I-set on papilin
- Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
- Immunoglobulin V-Type
- immunoglobulin domain
- ADAMTS cysteine-rich domain
- Immunoglobulin I-set domain
- PLAC (protease and lacunin) domain
- ADAM-TS Spacer 1
- Immunoglobulin like
- Spondin-like TSP1 domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PAPLN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix organization
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity