KIF2C
KIF2C Gene Summary
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | KIF2C |
| Official Name | kinesin family member 2C [Source:HGNC Symbol;Acc:HGNC:6393] |
| Ensembl ID | ENSG00000142945 |
| Bio databases IDs | |
| Aliases | kinesin family member 2C |
| Synonyms | 4930402F02Rik,CT139,ESTM5,kinesin family member 2C,KNSL6,KRP2,MCAK |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin motor, catalytic domain
- microtubule binding
- Myosin and Kinesin motor domain
- Kinesin motor domain
- microtubule plus-end binding
- protein binding
- centromeric DNA binding
- motor domain
- microtubule motor protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- NXF1
- ERLIN2
- ZRANB1
- NPIPB3
- MYH9
- SLC4A2
- MYC
- STK3
- CDC5L
- PRKN
disease
- neoplasia
- head and neck squamous cell carcinoma
- breast cancer
- liver cancer
- cancer
- metastasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- hepatocellular carcinoma
- epithelial cancer
regulated by
- ZBTB17
- NS
- NR1H3
- AR
- IL6
- cisplatin
- methotrexate
- ifosfamide
- doxorubicin
- ACHE
regulates
- IL1B
- AKT
- CTNNB1
- KIF2C
- CDKN1A
- TP53
- GSK3B
- IL18
role in cell
- cell viability
- proliferation
- S phase
- apoptosis
- migration
- formation
- length
- stability
- disassembly
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule aster fraction
- glutaminergic synapse
- microtubule cytoskeleton
- Cytoplasm
- presynaptic regions
- postsynaptic region
- centrosome
- microtubules
- midbody
- cytosol
- cytoplasmic microtubule
- central spindle
- mitotic spindle
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the KIF2C gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of chromosome segregation
- cell division
- metaphase plate congression
- microtubule-based movement
- mitotic metaphase plate congression
- microtubule depolymerization
- attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
- establishment or maintenance of microtubule cytoskeleton polarity
CELLULAR COMPONENT
Where in the cell the gene product is active
- microtubule cytoskeleton
- microtubule plus end
- kinesin complex
- cytoplasmic microtubule
- kinetochore
- chromosome, centromeric region
- microtubule
- nucleus
- centrosome
- membrane
- spindle
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- protein binding
- microtubule plus-end binding
- centromeric DNA binding
- microtubule binding