CINP Gene Summary [Human]

The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Details

Type
Nonsense Mediated Decay
Official Symbol
CINP
Official Name
cyclin dependent kinase 2 interacting protein [Source:HGNC Symbol;Acc:HGNC:23789]
Ensembl ID
ENSG00000100865
Bio databases IDs NCBI: 51550 Ensembl: ENSG00000100865
Aliases cyclin dependent kinase 2 interacting protein
Synonyms 1810047K05Rik, 2810452K22RIK, cyclin-dependent kinase 2-interacting protein, RGD1563395
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CINP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ribonucleoprotein binding
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • rheumatoid arthritis
  • covid-19 death
regulated by
regulates
role in cell
  • phosphorylation in
  • expression in
  • proliferation
  • talazoparib sensitivity

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CINP gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell division
  • DNA repair
  • DNA replication
  • ribosomal large subunit biogenesis

Cellular Component

Where in the cell the gene product is active
  • nucleus

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

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