ANGPT4 Gene Summary [Human]
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ANGPT4 |
| Official Name | angiopoietin 4 [Source:HGNC Symbol;Acc:HGNC:487] |
| Ensembl ID | ENSG00000101280 |
| Bio databases IDs | |
| Aliases | angiopoietin 4 |
| Synonyms | AGPT4, ANG-3, ANG-4, angiopoietin 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANGPT4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transmembrane receptor protein tyrosine kinase activator
- receptor tyrosine kinase binding
- fibrinogen-like domain
- vascular endothelial growth factor receptor binding
- FReD
- growth factor
Pathways
Biological processes and signaling networks where the ANGPT4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- Alzheimer disease
- epithelial cancer
- schwannoma
- peanut allergy
- diabetic nephropathy
- gastrointestinal stromal tumor
- gastrointestinal stromal neoplasia
- posterior cortical atrophy
role in cell
- apoptosis
- phosphorylation in
- number
- tyrosine phosphorylation in
- permeability
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANGPT4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- negative regulation of blood vessel endothelial cell migration
- signal transduction
- positive regulation of blood vessel endothelial cell migration
- positive regulation of angiogenesis
- Notch signaling pathway
- angiogenesis
- negative regulation of apoptotic process
- endothelial cell proliferation
- cellular response to hypoxia
- positive regulation of endothelial cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- transmembrane receptor protein tyrosine kinase activator activity
- receptor tyrosine kinase binding