NOS3 Gene Summary [Human]
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | NOS3 |
| Official Name | nitric oxide synthase 3 [Source:HGNC Symbol;Acc:HGNC:7876] |
| Ensembl ID | ENSG00000164867 |
| Bio databases IDs | |
| Aliases | nitric oxide synthase 3, endothelial nitric oxide synthase |
| Synonyms | 2310065A03Rik, ECNOS, eNOS, nitric oxide synthase 3, nitric oxide synthase 3, endothelial cell |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- FAD binding domain
- Nitric oxide synthase, oxygenase domain
- heat shock protein binding
- enzyme
- NADPH-dependent FMN reductase
- NOS_oxygenase
- actin binding
- cadherin binding
- oxygenase domain
- calmodulin binding
- beta-catenin binding
- calmodulin binding domain
- nitric-oxide synthase
- flavodoxin
- enzyme binding
- heme binding domain
- protein binding
- heme binding
- superoxide-generating NADPH oxidase
- phosphorylation site
- amino acid binding
- reductase domain
- binding protein
- actin monomer binding
- hinge domain
- Oxidoreductase NAD-binding domain
Pathways
Biological processes and signaling networks where the NOS3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- Apelin Cardiac Fibroblast Signaling Pathway
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- Erythropoietin Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- Hypoxia Signaling in the Cardiovascular System
- Inhibition of Angiogenesis by TSP1
- Nitric Oxide Signaling in the Cardiovascular System
- Opioid Signaling Pathway
- Sertoli Cell-Sertoli Cell Junction Signaling
- Synaptic Long Term Depression
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- atopic dermatitis
- ulcerative colitis
- proteinuria
- stroke
- hypertension
- essential hypertension
- myocardial infarction
- albuminuria
- Alzheimer disease
role in cell
- phosphorylation in
- expression in
- production in
- chemotaxis
- cell death
- proliferation
- activation in
- migration
- contraction
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- caveolae fraction
- detergent-insoluble fractions
- membrane fraction
- endocytic vesicle membrane
- perinuclear Golgi regions
- cell surface
- Golgi region
- cell periphery
- intracellular space
- apical compartment
- perinuclear region
- intracellular membranes
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Mitochondria
- intercellular junctions
- cytoplasmic particles
- cytosol
- primary cilia
- cytoplasmic face of plasma membrane
- plasma membrane extracellular face
- caveolar membranes
- caveolae
- basolateral membrane
- Golgi membrane
- mitochondrial outer membrane
- neurites
- sarcolemma
- Z line
- membrane rafts
- filopodia
- perikaryon
- axons
- lamellipodia
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of muscle hyperplasia
- positive regulation of guanylate cyclase activity
- negative regulation of cell proliferation
- vasodilation
- negative regulation of potassium ion transport
- endothelial cell migration
- regulation of the force of heart contraction by chemical signal
- positive regulation of Notch signaling pathway
- positive regulation of angiogenesis
- potassium ion transport
- endocardial cushion morphogenesis
- ovulation from ovarian follicle
- response to heat
- angiogenesis
- in utero embryonic development
- negative regulation of smooth muscle cell proliferation
- calcium ion transport
- negative regulation of calcium ion transport
- negative regulation of biomineral tissue development
- establishment of localization in cell
- response to fluid shear stress
- lung development
- aortic valve morphogenesis
- nitric oxide mediated signal transduction
- pulmonary valve morphogenesis
- negative regulation of blood pressure
- cell redox homeostasis
- regulation of systemic arterial blood pressure by endothelin
- response to hormone stimulus
- ventricular septum morphogenesis
- regulation of blood pressure
- mitochondrion organization
- positive regulation of blood vessel endothelial cell migration
- arginine catabolic process
- regulation of sodium ion transport
- blood vessel remodeling
- homeostasis of number of cells within a tissue
- smooth muscle hyperplasia
- removal of superoxide radicals
- positive regulation of gene expression
- negative regulation of platelet activation
- lipopolysaccharide-mediated signaling pathway
- response to lipopolysaccharide
- nitric oxide biosynthetic process
- regulation of neurological system process
Cellular Component
Where in the cell the gene product is active
- nucleus
- caveola
- cytoskeleton
- cytoplasm
- cytosol
- Golgi apparatus
- Golgi membrane
- endocytic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- FMN binding
- heme binding
- actin monomer binding
- scaffold protein binding
- arginine binding
- calmodulin binding
- tetrahydrobiopterin binding
- NADP binding
- protein binding
- nitric-oxide synthase activity
- flavin adenine dinucleotide binding
- cadmium ion binding