KIF4A Gene Summary [Human]
This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | KIF4A |
| Official Name | kinesin family member 4A [Source:HGNC Symbol;Acc:HGNC:13339] |
| Ensembl ID | ENSG00000090889 |
| Bio databases IDs | |
| Aliases | kinesin family member 4A, chromokinesin |
| Synonyms | D330050K22Rik, KIF4, KIF4G1, kinesin family member 4, kinesin family member 4A, Kns4, MRX100, TMDI, XLID100 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF4A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin motor, catalytic domain
- microtubule binding
- Myosin and Kinesin motor domain
- Synaptonemal complex protein 1 (SCP-1)
- Kinesin motor domain
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- protein binding
- microtubule motor protein
- HOOK protein coiled-coil region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- metastasis
- primary breast cancer
- X-linked mental retardation type 100
- non-small cell lung cancer
- mammary neoplasm
- non-small cell lung carcinoma
- survival
- urothelial bladder carcinoma
role in cell
- expression in
- phosphorylation in
- proliferation
- growth
- quantity
- apoptosis
- degradation in
- production in
- formation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microsomal fraction
- nuclear fraction
- microtubule aster fraction
- Cytoplasm
- contractile rings
- midbody
- cytosol
- chromosome
- nucleoplasm
- spindle fibers
- nuclear matrix
- growth cone
- central spindle
- mitotic spindle
- chromosomal arms
- perikaryon
- axons
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF4A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle midzone assembly involved in mitosis
- anterograde axon cargo transport
- spindle elongation
- cytokinesis after mitosis
- mitotic spindle organization
- organelle organization
Cellular Component
Where in the cell the gene product is active
- spindle microtubule
- cytoplasm
- membrane
- cytosol
- nuclear matrix
- midbody
- chromosome
- microtubule associated complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ATP binding
- microtubule motor activity
- protein binding
- metal ion binding
- iron-sulfur cluster binding
- microtubule binding