UBL4A Gene Summary [Human]
Enables chaperone binding activity. Involved in tail-anchored membrane protein insertion into ER membrane. Located in cytosol; membrane; and nucleoplasm. Part of BAT3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | UBL4A |
| Official Name | ubiquitin like 4A [Source:HGNC Symbol;Acc:HGNC:12505] |
| Ensembl ID | ENSG00000102178 |
| Bio databases IDs | |
| Aliases | ubiquitin like 4A |
| Synonyms | DX254E, DXHXS254E, DXS254E, DXS254Eh, G6PD, GDX, GET5, MDY2, RGD1563983, TMA24, ubiquitin-like 4A, Ubiquitin-like protein 4A, UBL4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBL4A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- ubiquitin-like protein transferase activity
- Tethering Ubl4a to BAGS domain
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- enzyme
- protein binding
- chaperone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cyanosis
- tumorigenesis
- hyperplasia
- collagen-induced arthritis
role in cell
- phosphorylation in
- binding in
- killing
- quantity
- dephosphorylation in
- recruitment in
- tumorigenicity
- proliferative capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBL4A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- regulation of protein stability
- tail-anchored membrane protein insertion into ER membrane
- posttranslational protein targeting to membrane
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- BAT3 complex
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chaperone binding
- small conjugating protein ligase activity