AGRP Gene Summary [Human]
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
Details
| Type | Protein Coding |
| Official Symbol | AGRP |
| Official Name | agouti related neuropeptide [Source:HGNC Symbol;Acc:HGNC:330] |
| Ensembl ID | ENSG00000159723 |
| Bio databases IDs | |
| Aliases | agouti related neuropeptide |
| Synonyms | agouti related neuropeptide, AGRT, ANTI-SATIETY PEPTIDE, ART, ASIP2, Marp |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGRP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- hormone
- receptor binding
- neuropeptide hormone
- Agouti protein
- cysteine rich domain
Pathways
Biological processes and signaling networks where the AGRP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- hyperphagia
- weight gain
- starvation
- inherited leanness
- migraines
- adult-onset obesity
- diabetes mellitus
- delayed puberty
- cachexia
role in cell
- activation in
- accumulation
- interaction in
- endocytosis by
- inhibition
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- cell periphery
- Nucleus
- perikaryon
- axons
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGRP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-day photoperiodism
- neuropeptide signaling pathway
- response to insulin stimulus
- maternal process involved in female pregnancy
- feeding behavior
- positive regulation of feeding behavior
- adult feeding behavior
- circadian rhythm
- regulation of feeding behavior
- eating behavior
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- neuronal cell body
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- neuropeptide hormone activity
- type 1 melanocortin receptor binding
- receptor binding