ARL2BP Gene Summary [Human]
ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | ARL2BP |
| Official Name | ADP ribosylation factor like GTPase 2 binding protein [Source:HGNC Symbol;Acc:HGNC:17146] |
| Ensembl ID | ENSG00000102931 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor like GTPase 2 binding protein, binder of Arl2 |
| Synonyms | 1700010P10Rik, 1700027H16Rik, 6330544B05Rik, ADP-ribosylation factor-like 2 binding protein, ARF like GTPase 2 binding protein, BART, BART1, RP66, RP82 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARL2BP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- GTPase regulator
- transcription co-activator
- The ARF-like 2 binding protein BART
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinitis pigmentosa with or without situs inversus
- retinitis pigmentosa
- autosomal recessive retinitis pigmentosa
- retinal dystrophy
regulated by
regulates
role in cell
- proliferation
- degeneration
- disorganization
- disorganization in
- shortening in
- shortening
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- basal bodies
- centrosome
- Mitochondria
- midbody
- cytosol
- mitochondrial matrix
- mitochondrial intermembrane space
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARL2BP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of transcription, DNA-dependent
- positive regulation of tyrosine phosphorylation of STAT protein
- maintenance of protein location in nucleus
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- centrosome
- mitochondrial matrix
- spindle
- cilium
- cytosol
- midbody
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- GTPase regulator activity