HNRNPLL Gene Summary [Human]
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]
Details
| Type | Protein Coding |
| Official Symbol | HNRNPLL |
| Official Name | heterogeneous nuclear ribonucleoprotein L like [Source:HGNC Symbol;Acc:HGNC:25127] |
| Ensembl ID | ENSG00000143889 |
| Bio databases IDs | |
| Aliases | heterogeneous nuclear ribonucleoprotein L like |
| Synonyms | 2510028H02Rik, 2810036L13Rik, heterogeneous nuclear ribonucleoprotein L-like, HNRPLL, RGD1305861, SRRF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HNRNPLL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RRM-like domain
- RNA recognition motif (RRM) superfamily
- hnRNP-L/PTB/hephaestus splicing factor family
- RNA recognition motif
- mRNA binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
role in cell
- expression in
- production in
- phosphorylation in
- alternative splicing in
- oxidative phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Nucleus
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HNRNPLL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of RNA splicing
- positive regulation of RNA splicing
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- synapse
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding