Arl2bp Gene Summary [Mouse]
Predicted to enable GTPase regulator activity and transcription coactivator activity. Predicted to be involved in maintenance of protein location in nucleus and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in several cellular components, including centrosome; midbody; and nucleoplasm. Predicted to be active in mitochondrial intermembrane space. Is expressed in genitourinary system. Used to study male infertility and retinitis pigmentosa with or without situs inversus. Human ortholog(s) of this gene implicated in retinitis pigmentosa with or without situs inversus. Orthologous to human ARL2BP (ARF like GTPase 2 binding protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arl2bp |
| Official Name | ADP-ribosylation factor-like 2 binding protein [Source:MGI Symbol;Acc:MGI:1349429] |
| Ensembl ID | ENSMUSG00000031776 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor-like 2 binding protein |
| Synonyms | 1700010P10Rik, 1700027H16Rik, 6330544B05Rik, ADP-ribosylation factor-like 2 binding protein, ARF like GTPase 2 binding protein, BART, BART1, RP66, RP82 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arl2bp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- GTPase regulator
- transcription co-activator
- The ARF-like 2 binding protein BART
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinitis pigmentosa with or without situs inversus
- retinitis pigmentosa
- autosomal recessive retinitis pigmentosa
- retinal dystrophy
regulated by
regulates
- STAT
role in cell
- proliferation
- degeneration
- disorganization
- disorganization in
- shortening in
- shortening
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- basal bodies
- centrosome
- Mitochondria
- midbody
- cytosol
- mitochondrial matrix
- mitochondrial intermembrane space
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arl2bp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of transcription, DNA-dependent
- positive regulation of tyrosine phosphorylation of STAT protein
- maintenance of protein location in nucleus
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- centrosome
- mitochondrial matrix
- spindle
- cilium
- cytosol
- midbody
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- GTPase regulator activity