EEF2K Gene Summary [Human]
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | EEF2K |
| Official Name | eukaryotic elongation factor 2 kinase [Source:HGNC Symbol;Acc:HGNC:24615] |
| Ensembl ID | ENSG00000103319 |
| Bio databases IDs | |
| Aliases | eukaryotic elongation factor 2 kinase |
| Synonyms | AC241556.4, CaMKIII, eEF-2 kinase, eukaryotic elongation factor-2 kinase, HSU93850, LOC100504422, LOC101060570, SMEF2K |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EEF2K often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Alpha kinase family
- nucleic acid binding translation factor
- protein serine/threonine kinase
- protein kinase
- eEF2 binding domain
- calmodulin binding
- catalytic domain
- eukaryotic elongation factor-2 kinase
- Alpha-kinase family
Pathways
Biological processes and signaling networks where the EEF2K gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- abdominal aortic aneurysm
- Alzheimer disease
- organismal death
- collagen-induced arthritis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
role in cell
- autophagy by
- proliferation
- apoptosis
- cell death
- survival
- phosphorylation in
- expression in
- cell viability
- growth
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytosol
- dendritic spines
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EEF2K gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of dendritic spine morphogenesis
- positive regulation of endocytosis
- protein autophosphorylation
- translational elongation
- cellular response to insulin stimulus
- response to ischemia
- cellular response to calcium ion
- cellular response to anoxia
- negative regulation of apoptotic process
- cellular response to cAMP
- regulation of protein autophosphorylation
- positive regulation of synapse assembly
- myosin II filament disassembly
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytoplasm
- dendritic spine
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- calcium ion binding
- translation factor activity, nucleic acid binding
- protein kinase activity
- elongation factor-2 kinase activity