EEF2 Gene Summary [Human]
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | EEF2 |
| Official Name | eukaryotic translation elongation factor 2 [Source:HGNC Symbol;Acc:HGNC:3214] |
| Ensembl ID | ENSG00000167658 |
| Bio databases IDs | |
| Aliases | eukaryotic translation elongation factor 2, polypeptidyl-tRNA translocase |
| Synonyms | AK190557, eEF-2 histidine, EF-2, EUKARYOTIC TRANSLATION ELONGATION FACTOR 2, LOC102553232, SCA26, Similar to mapkk, Transferase II |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EEF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- translation elongation factor
- 5S rRNA binding
- 50S ribosome-binding GTPase
- Domain III of Elongation factor G (EF-G) and related proteins
- GTPase
- translation elongation factor EF-G
- p53 binding
- protein binding
- Elongation factor Tu domain 2
- EFG_like_IV
- Elongation_Factor_C
- translation regulator
- RNA binding
- actin filament binding
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- Elongation factor G C-terminus
- elongation factor G-like protein
- ribosome binding
- translation elongation factor aEF-2
- Elongation factor Tu GTP binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- Elongation factor G, domain IV
Pathways
Biological processes and signaling networks where the EEF2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- epithelial cancer
- organismal death
- hepatitis C virus-related hepatocellular carcinoma
- liver cancer
- celiac disease
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- hepatitis B surface antigen-negative hepatitis C virus negative hepatocellular carcinoma
- spinocerebellar ataxia type 26
role in cell
- proliferation
- cell death
- differentiation
- cell viability
- molecular cleavage in
- autophagy in
- aneuploidy
- colony formation by
- synthesis in
- elongation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- detergent resistant lipid raft fraction
- aggresome
- glutaminergic synapse
- extracellular vesicles
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cellular membrane
- ribosome
- Nucleus
- Plasma Membrane
- cytosol
- synaptic vesicles
- synapse
- perikaryon
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EEF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- translational elongation
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- secretory granule lumen
- synapse
- extracellular region
- ribosome
- aggresome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- RNA binding
- protein binding
- translation elongation factor activity
- cadherin binding
- ribosome binding
- GTPase activity