Eef2k Gene Summary [Rat]
Enables elongation factor-2 kinase activity. Involved in several processes, including cellular response to anoxia; cellular response to brain-derived neurotrophic factor stimulus; and positive regulation of cellular component organization. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human EEF2K (eukaryotic elongation factor 2 kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eef2k |
| Official Name | eukaryotic elongation factor-2 kinase [Source:RGD Symbol;Acc:2538] |
| Ensembl ID | ENSRNOG00000016448 |
| Bio databases IDs | |
| Aliases | eukaryotic elongation factor-2 kinase |
| Synonyms | AC241556.4, CaMKIII, eEF-2 kinase, eukaryotic elongation factor-2 kinase, HSU93850, LOC100504422, LOC101060570, SMEF2K |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eef2k often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Alpha kinase family
- nucleic acid binding translation factor
- protein serine/threonine kinase
- protein kinase
- eEF2 binding domain
- calmodulin binding
- catalytic domain
- eukaryotic elongation factor-2 kinase
- Alpha-kinase family
Pathways
Biological processes and signaling networks where the Eef2k gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- abdominal aortic aneurysm
- Alzheimer disease
- organismal death
- collagen-induced arthritis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
role in cell
- autophagy by
- proliferation
- apoptosis
- cell death
- survival
- phosphorylation in
- expression in
- cell viability
- growth
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytosol
- dendritic spines
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eef2k gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of dendritic spine morphogenesis
- positive regulation of endocytosis
- protein autophosphorylation
- translational elongation
- cellular response to insulin stimulus
- response to ischemia
- cellular response to calcium ion
- cellular response to anoxia
- negative regulation of apoptotic process
- cellular response to cAMP
- regulation of protein autophosphorylation
- positive regulation of synapse assembly
- myosin II filament disassembly
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytoplasm
- dendritic spine
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- calcium ion binding
- translation factor activity, nucleic acid binding
- protein kinase activity
- elongation factor-2 kinase activity