GGA2 Gene Summary [Human]
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GGA2 |
| Official Name | golgi associated, gamma adaptin ear containing, ARF binding protein 2 [Source:HGNC Symbol;Acc:HGNC:16064] |
| Ensembl ID | ENSG00000103365 |
| Bio databases IDs | |
| Aliases | golgi associated, gamma adaptin ear containing, ARF binding protein 2 |
| Synonyms | 1200007E24Rik, golgi associated, gamma adaptin ear containing, ARF binding protein 2, golgi associated, γ adaptin ear containing, ARF binding protein 2, LOC100293916, LOC103694867, mKIAA1080, VEAR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GGA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GAT_SF
- N-terminal extension of GAT domain
- GAE domain
- Adaptin C-terminal domain
- enzyme binding
- protein binding
- proline rich domain
- Domain present in VPS-27, Hrs and STAM
- ear domain
- GGA homology domain
- hinge domain
- VHS, ENTH and ANTH domain superfamily
- GAT domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- cellular membrane
- Plasma Membrane
- endosomes
- Golgi Apparatus
- cytoplasmic aggregates
- Golgi buds
- trans Golgi network
- endosomal membrane
- clathrin-coated vesicles
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GGA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- Golgi to plasma membrane transport
- Golgi to plasma membrane protein transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- trans-Golgi network
- Golgi apparatus
- endosome membrane
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- phosphatidylinositol binding
- small GTPase binding