NECAP2 Gene Summary [Human]

This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Details

Type
Protein Coding
Official Symbol
NECAP2
Official Name
NECAP endocytosis associated 2 [Source:HGNC Symbol;Acc:HGNC:25528]
Ensembl ID
ENSG00000157191
Bio databases IDs NCBI: 55707 Ensembl: ENSG00000157191
Aliases NECAP endocytosis associated 2, adaptin-ear-binding coat-associated protein 2
Synonyms 1110005F07RIK, FLJ10420, NECAP endocytosis associated 2, NECP2
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NECAP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Protein of unknown function (DUF1681)
  • protein binding
  • Pleckstrin homology-like domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • severe acute respiratory syndrome
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cellular membrane
  • cytosol
  • clathrin-coated pits
  • clathrin-coated vesicles

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human NECAP2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • vesicle-mediated transport
  • protein transport
  • endocytosis

Cellular Component

Where in the cell the gene product is active
  • coated pit
  • clathrin vesicle coat
  • plasma membrane

Gene-Specific Assays for Results You Can Trust

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