VPS18 Gene Summary [Human]
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | VPS18 |
| Official Name | VPS18 core subunit of CORVET and HOPS complexes [Source:HGNC Symbol;Acc:HGNC:15972] |
| Ensembl ID | ENSG00000104142 |
| Bio databases IDs | |
| Aliases | VPS18 core subunit of CORVET and HOPS complexes |
| Synonyms | 9930024E13RIK, mVps18, PEP3, VPS18 core subunit of CORVET and HOPS complexes, VPS18 CORVET/HOPS core subunit, VPS18 isoform 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VPS18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- actin binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- coiled-coil domain
- Region in Clathrin and VPS
- protein binding
- Pep3/Vps18/deep orange family
- Clathrin heavy chain repeat homology
- Zinc finger, C3HC4 type (RING finger)
- syntaxin binding
Pathways
Biological processes and signaling networks where the VPS18 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodegeneration
role in cell
- migration
- entrance
- organization
- ipatasertib sensitivity
- dipeptide repeat protein sensitivity
- palbociclib resistance
- degradation in
- production in
- upregulation in
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- presynaptic regions
- cell periphery
- cellular membrane
- endosomes
- vesicles
- lysosome
- actin filaments
- cytosol
- lysosome membrane
- endosomal membrane
- early endosomes
- late endosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VPS18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- lysosome organization
- regulation of SNARE complex assembly
- endosome organization
- endosome to lysosome transport
- intracellular protein transport
- organelle fusion
- autophagy
- vesicle docking involved in exocytosis
- regulation of synaptic vesicle exocytosis
- negative regulation of intracellular estrogen receptor signaling pathway
- endosomal vesicle fusion
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- CORVET complex
- late endosome
- actin filament
- lysosomal membrane
- autophagic vacuole
- lysosome
- late endosome membrane
- early endosome
- endosome
- endosome membrane
- AP-3 adaptor complex
- clathrin-coated vesicle
- HOPS complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- syntaxin binding
- metal ion binding
- protein binding, bridging