PICK1
PICK1 Gene Summary
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PICK1 |
| Official Name | protein interacting with PRKCA 1 [Source:HGNC Symbol;Acc:HGNC:9394] |
| Ensembl ID | ENSG00000100151 |
| Bio databases IDs | |
| Aliases | protein interacting with PRKCA 1 |
| Synonyms | PICK,PRKCABP,protein interacting with C kinase 1,protein interacting with PRKCA 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- SNAP receptor
- protein kinase C binding
- G-protein-coupled receptor binding
- canonical PDZ domain
- enzyme binding
- ephrin receptor binding
- coiled-coil domain
- protein domain specific binding
- enzyme
- protein binding
- receptor binding
- PDZ domain
- ionotropic glutamate receptor binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- acidic domain
- actin filament binding
- binding protein
- cytoskeletal protein binding
- receptor tyrosine kinase binding
- Arfaptin-like domain
Pathways
Biological processes and signaling networks where the PICK1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- AEBP2
- SLC6A3
- NSF
- SNAP
- GRIA2
- CEP290
- NLGN1
- EPHB2
- ZNF24
- NHSL2
disease
- non-insulin-dependent diabetes mellitus
- placenta accreta spectrum
- asthenozoospermia
- teratozoospermia
- amphetamine delusional disorder
- oligozoospermia
- organismal death
- globozoospermia
- neurodegeneration
- drug abuse
regulated by
- N-methyl-D-aspartate
- Ca2+
- ZDHHC8
- NAPB
- PICK1
- p30II
- ASIC2
- D-glucose
- GSK3B
- phorbol 12,13-didecanoate
regulates
- reactive oxygen species
- D-glucose
- insulin
- water
- proinsulin
- GRIA2
- SLC1A1
- GRM3
- ARRB2
- NPHS1
role in cell
- expression in
- apoptosis
- quantity
- activation
- organization
- survival
- development
- response by
- endocytosis by
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- endocytic vesicle membrane
- organelle
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- presynaptic membrane
- postsynaptic membrane
- trans Golgi network
- perinuclear space
- insulin secretory granules
- dendritic spines
- synaptic vesicles
- growth cone
- neurites
- synaptosomes
- synapse
- early endosomes
- perinuclear vesicles
- perikaryon
- dendrites
- postsynaptic density
- penicillate terminals
- dendritic shafts
- dendritic branches
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PICK1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of receptor internalization
- retrograde vesicle-mediated transport, Golgi to ER
- dendritic spine organization
- receptor clustering
- protein kinase C-activating G-protein coupled receptor signaling pathway
- glial cell development
- protein phosphorylation
- intracellular protein transport
- dendritic spine maintenance
- cellular response to glucose starvation
- regulation of insulin secretion
- neuronal ion channel clustering
- long term synaptic depression
- monoamine transport
- negative regulation of Arp2/3 complex-mediated actin nucleation
- regulation of Arp2/3 complex-mediated actin nucleation
CELLULAR COMPONENT
Where in the cell the gene product is active
- presynaptic membrane
- postsynaptic density
- synaptic vesicle
- Golgi apparatus
- synapse
- neuron projection
- plasma membrane
- cytoskeleton
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- endocytic vesicle membrane
- trans-Golgi network membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein kinase C binding
- actin filament binding
- G-protein coupled receptor binding
- identical protein binding
- protein domain specific binding
- protein binding
- metal ion binding
- phospholipid binding
- receptor binding
- Arp2/3 complex binding