TF
TF Gene Summary
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | TF |
| Official Name | transferrin [Source:HGNC Symbol;Acc:HGNC:11740] |
| Ensembl ID | ENSG00000091513 |
| Bio databases IDs | |
| Aliases | transferrin, serotransferrin |
| Synonyms | Apo-Tf,Apo-transferrin,Cd176,HEL-S-71p,Holo-Tf,Holo-transferrin,HP,hpx,Liver regeneration related protein lrrg03,Liver Reneration-related,PRO1557,PRO2086,Serotransferrin,Serotransferrin precursor,Tfn,TFQTL1,TRANSFERRIN,Trf |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- ferric iron binding
- Type 2 periplasmic binding fold superfamily
- ion channel binding
- enzyme binding
- protein binding
- receptor binding
- metallochaperone
- Transferrin
- glycosylation site
- ABC transporter, phosphonate, periplasmic substrate-binding protein
- transporter
Pathways
Biological processes and signaling networks where the TF gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TCF3
- HA
- DDX31
- TLE4
- RMDN3
- SERPINA3
- ESR1
- ALDH2
- MID2
- HDAC5
disease
- metastatic gastric adenocarcinoma
- gastroesophageal junction adenocarcinoma
- non-insulin-dependent diabetes mellitus
- disorder of coronary artery
- heart failure
- cirrhosis
- renal impairment
- metastatic gastroesophageal junction adenocarcinoma
- gastric adenocarcinoma
- metastatic breast cancer
regulated by
- lipopolysaccharide
- SREBF1
- Immunoglobulin
- GPER1
- TNF
- TPD52L2
- PACSIN2
- Cote d'Ivoire ebolavirus
- CREB
- P2RY2
regulates
- ACOX1
- cyclic AMP
- IL6
- IL2
- TF
- INS
- CCL2
- TGFA
- DNA promoter
- synthetic promoter
role in cell
- proliferation
- expression in
- cell viability
- degradation in
- apoptosis
- induction in
- phosphorylation in
- cell death
- survival
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- myelin enriched fraction
- early endosome-associated tubule
- endocytic vesicle membrane
- secretory granule lumen
- Cytoplasm
- cell surface
- basal compartment
- perinuclear region
- pericentriolar regions
- punctate structures
- cellular membrane
- vacuole
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- Mitochondria
- granules
- endoplasmic reticulum lumen
- apical membrane
- basolateral membrane
- basal membrane
- lysosomal compartment
- endosomal compartment
- endosomal membrane
- perinuclear space
- recycling endosomes
- early endosomes
- late endosomes
- perinuclear vesicles
- cytoplasmic vesicles
- endocytotic vesicle
- peripheral vesicles
- cell tip
- clathrin-coated pits
- dendrites
- sorting endosomes
- brush border membrane vesicles
- plasma
- basement membrane
- perinuclear recycling endosome
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TF gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of phosphorylation
- actin filament organization
- cellular response to iron ion
- cellular iron ion homeostasis
- ERK1 and ERK2 cascade
- osteoclast differentiation
- regulation of protein stability
- positive regulation of transcription, DNA-dependent
- iron ion transport
- positive regulation of bone resorption
- antibacterial humoral response
- positive regulation of receptor-mediated endocytosis
- regulation of iron ion transport
- positive regulation of cell motility
CELLULAR COMPONENT
Where in the cell the gene product is active
- late endosome
- extracellular region
- plasma membrane
- cell surface
- endocytic vesicle
- endoplasmic reticulum lumen
- early endosome
- basal plasma membrane
- extracellular space
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- clathrin-coated endocytic vesicle membrane
- basal part of cell
- coated pit
- blood microparticle
- vesicle
- cytoplasmic vesicle
- endosome membrane
- recycling endosome
- secretory granule lumen
- apical plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- ferric iron binding
- ferrous iron binding
- iron chaperone activity