BRF2 Gene Summary [Human]
This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | BRF2 |
| Official Name | BRF2 RNA polymerase III transcription initiation factor subunit [Source:HGNC Symbol;Acc:HGNC:17298] |
| Ensembl ID | ENSG00000104221 |
| Bio databases IDs | |
| Aliases | BRF2 RNA polymerase III transcription initiation factor subunit |
| Synonyms | 2700059M06Rik, 5730512K07Rik, BRF2 general transcription factor 3B subunit, BRF2 general transcription factor IIIB subunit, BRF2, RNA polymerase III transcription initiation factor 50kDa subunit, BRFU, Pol III, TFIIIB50 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BRF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- Cyclin box fold superfamily
- protein binding
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the BRF2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- breast carcinoma
- breast cancer
- organismal death
- ductal breast carcinoma
- ductal breast cancer
- atopic dermatitis
role in cell
- growth
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BRF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to oxidative stress
- DNA-dependent transcriptional preinitiation complex assembly
- transcription initiation, DNA-dependent
- regulation of transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIIIB complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- TBP-class protein binding
- RNA polymerase III type 3 promoter sequence-specific DNA binding