SMAP1 Gene Summary [Human]
The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SMAP1 |
| Official Name | small ArfGAP 1 [Source:HGNC Symbol;Acc:HGNC:19651] |
| Ensembl ID | ENSG00000112305 |
| Bio databases IDs | |
| Aliases | small ArfGAP 1 |
| Synonyms | 1700056O10Rik, 4921514B13Rik, 4921525H11Rik, small ArfGAP 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SMAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative GTP-ase activating proteins for the small GTPase, ARF
- clathrin binding
- GTPase activator
- protein binding
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Putative GTPase activating protein for Arf
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SMAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of clathrin-mediated endocytosis
- positive regulation of erythrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- GTPase activator activity
- clathrin binding